Interleukin-lp Induces Production of Granulocyte Colony-Stimulating Factor in Human Hepatoma Cells
نویسندگان
چکیده
Interleukin-1 (IL-1) is a proinflammatory cytokine that participates in the activation of the acute-phase plasma protein genes in hepatic cells during infection and injury. In human hepatoma HepG2 and Hep3B cells, IL-1fi induced production of the granulocyte colony-stimulating factor (G-CSF) in a dose-dependent manner. Activation of G-CSF gene expression was an early and transient response. In HepG2 cells, GCSF mRNA was strongly upregulated 2 hours after IL-lfi treatment and returned to the pretreatment level by 6 hours. The secreted G-CSF was biologically active, as shown by the
منابع مشابه
Interleukin-1 beta induces production of granulocyte colony-stimulating factor in human hepatoma cells.
Interleukin-1 (IL-1) is a proinflammatory cytokine that participates in the activation of the acute-phase plasma protein genes in hepatic cells during infection and injury. In human hepatoma HepG2 and Hep3B cells, IL-1 beta induced production of the granulocyte colony-stimulating factor (G-CSF) in a dose-dependent manner. Activation of G-CSF gene expression was an early and transient response. ...
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